PHOENIX -- When he heard that Tim Wakefield was going to start for the Red Sox on Friday afternoon, Diamondbacks manager Bob Melvin was worried that trying to hit a knuckleball would mess up some of his hitters' swings.

He needn't have concerned himself as the Diamondbacks roughed up Wakefield and the Red Sox, 10-3, in front of 35,395 fans at Bank One Ballpark.

Wakefield (2-2) didn't survive the first inning as the first seven Arizona batters reached base against him. After he retired Craig Counsell for the inning's second out, Wakefield was removed by Boston manager Terry Francona.

By then, though, the damage had been done. The D-Backs scored six runs to erase an early 2-0 deficit, with former Red Sox first baseman Tony Clark driving in two runs during the inning with a single to center.

Arizona starter Brandon Webb (2-0) settled down after a shaky first inning to pick up the win. The right-hander did not allow a run after the two tallies in the first and wound up lasting six innings.

It was a complete turnaround from what occurred Thursday night at BOB, when the Red Sox jumped all over Arizona starter Russ Ortiz for six first-inning runs.