Fighting for their lives in the National League Wild Card race, the D-backs are hopeful a three-game set against the last-place Giants could offer them the boost they need, but recent results suggest it won't be that easy.
San Francisco has won nine of its last 11 games in Arizona and has fared well in the desert through the years.
The D-backs will have to halt that trend, if they want to gain ground on the Cincinnati Reds, who currently sit six games up in the race for the second NL Wild Card spot.
Tim Lincecum (7-13, 4.55 ERA) starts for the Giants, coming off a win over the Pirates on Saturday in which he lasted 5 1/3 innings and allowed three runs on three hits. The right-hander also walked four and he didn't make it through the sixth in his second straight start.
Lincecum will be facing his greatest foil in D-backs first baseman Paul Goldschmidt, the NL's RBI leader. Goldschmidt has nine hits with a double and five homers in 17 career at-bats against Lincecum.
"He hurts you when you make a mistake," Lincecum said. "And I tend to make more mistakes with him than with other hitters."
Right-hander Randall Delgado (4-4, 3.87 ERA) gets the ball for the D-backs in his first start since taking a no-hitter into the fifth in Philadelphia on Saturday.
The D-backs are in search of a deep outing from Delgado, with a bullpen that has stretched its limits this season. Arizona has played 20 extra-inning games -- one shy of the franchise mark.
With rosters set to expand, manager Kirk Gibson sees help on the way.
"We'll get some reinforcements on Sunday," Gibson said. "The thing is, even if they don't throw every day, they're warming up. Sometimes that bites you, too, and we're starting to see the residual effects from all the extra-inning games."
Giants: Besting the West
Though the Giants sit in last place, their 30-23 mark against NL West opponents is the best in the division.
On Wednesday, Giants manager Bruce Bochy talked about finishing strong, despite the club's current standing.
"We've got to come out here and give it our best every day, which shouldn't be -- but can be -- a little bit of an issue, because of what these guys have been through the last three years," Bochy said.
D-backs: Bloomquist returns
Infielder Willie Bloomquist, who had been out since June 27 with a pair of broken bones in his left hand, started at shortstop on Wednesday and notched three hits.
"It's been a long road, but it's good to be back," Bloomquist said. "I feel great, I've been feeling great since the day they let me swing the bat again".
Bloomquist has made two trips to the DL this year -- the first stemming from an oblique strain that caused him to miss the season's first two months.
• In 52 at-bats against Lincecum, D-backs catcher Miguel Montero has more strikeouts (13) than hits (9).
• Martin Prado was held without an RBI on Wednesday, after he had tied the D-backs' franchise-record with four straight multi-RBI games.
Friday: RHP Randall Delgado (4-4, 3.87) vs. RHP Tim Lincecum (7-13, 4.55)
Saturday: RHP Trevor Cahill (5-10, 4.39) vs. RHP Ryan Vogelsong (3-4, 5.58)
Sunday: LHP Patrick Corbin (13-4, 2.79) vs. TBA